The final spin from the coalescence of aligned-spin black-hole binaries

Determining the final spin of a black-hole (BH) binary is a question of key importance in astrophysics. Modelling this quantity in general is made difficult by the fact that it depends on the 7-dimensional space of parameters characterizing the two initial black holes. However, in special cases, when symmetries can be exploited, the description can become simpler. For black-hole binaries with unequal masses but with equal spins which are aligned with the orbital angular momentum, we show that the use of recent simulations and basic but exact constraints derived from the extreme mass-ratio limit allow to model this quantity with a simple analytic expression. Despite the simple dependence, the expression models very accurately all of the available estimates, with errors of a couple of percent at most. We also discuss how to use the fit to predict when a Schwarzschild BH is produced by the merger of two spinning BHs, when the total angular momentum of the spacetime ``flips'' sign, or under what conditions the final BH is ``spun-up'' by the merger. Finally, suggest an extension of the fit to include unequal-spin binaries, thus potentially providing a complete description of the final spin from the coalescence of generic black-hole binaries with spins aligned to the orbital angular momentum.Comment: Version matching the published one; small changes throughout to fit space constraints; corrects error in vii) about spin-up/dow

Numerical simulation of binary black hole spacetimes and a novel approach to outer boundary conditions

[no abstract

Gravitational-wave detectability of equal-mass black-hole binaries with aligned spins

Binary black-hole systems with spins aligned or anti-aligned to the orbital angular momentum provide the natural ground to start detailed studies of the influence of strong-field spin effects on gravitational wave observations of coalescing binaries. Furthermore, such systems may be the preferred end-state of the inspiral of generic supermassive binary black-hole systems. In view of this, we have computed the inspiral and merger of a large set of binary systems of equal-mass black holes with spins parallel to the orbital angular momentum but otherwise arbitrary. Our attention is particularly focused on the gravitational-wave emission so as to quantify how much spin effects contribute to the signal-to-noise ratio, to the horizon distances, and to the relative event rates for the representative ranges in masses and detectors. As expected, the signal-to-noise ratio increases with the projection of the total black hole spin in the direction of the orbital momentum. We find that equal-spin binaries with maximum spin aligned with the orbital angular momentum are more than "three times as loud" as the corresponding binaries with anti-aligned spins, thus corresponding to event rates up to 30 times larger. We also consider the waveform mismatch between the different spinning configurations and find that, within our numerical accuracy, binaries with opposite spins S_1=-S_2 cannot be distinguished whereas binaries with spin S_1=S_2 have clearly distinct gravitational-wave emissions. Finally, we derive a simple expression for the energy radiated in gravitational waves and find that the binaries always have efficiencies E_rad/M > 3.6%, which can become as large as E_rad/M = 10% for maximally spinning binaries with spins aligned with the orbital angular momentum.Comment: 18 pages, 11 figures, matches published versio

C1B domain peptide of protein kinase Cγ significantly suppresses growth of human colon cancer cells in vitro and in an in vivo mouse xenograft model through induction of cell cycle arrest and apoptosis

Two peptides derived from the C1B domain of protein kinase Cγ (PKCγ) were shown to associate with classical PKC isozymes and modulate their activities. These C1B peptides are designated C1B1 (amino acid residues 101-112) and C1B5 (residues 141-151). Since PKC enzyme activity is shown to be involved in colon cancer development, the effect of C1B peptides on the growth of various human colon cancer cell lines was examined in vitro and in vivo. Sub-micromolar to micromolar levels of both C1B peptides induced approximately 60-70% growth attenuation in multiple colon cancer cell lines in a soft agar tumor colony assay; however, C1B5 peptide was not cytotoxic to normal colon epithelial cells in two dimensional culture. The effect of C1B5 peptide on colony growth of COLO205 cells was reversed by treatment with the PKCα/β inhibitor, Ro-32-0432. C1B peptide treatment attenuated COLO205 cells via two mechanisms: 1) cell cycle arrest and 2) stimulation of apoptosis. This is evident in G[subscript 2] arrest and increases in levels of cleaved caspase 3 and p53 phosphorylated at serine 20. Intratumoral injection of C1B5 peptide (20 mg/kg/day, every three days) markedly attenuated the growth of subcutaneous xenografts of COLO205 cells in SCID mice by 76% compared to the control. Taken together, these results strongly suggest that C1B peptides have negligible effects on normal tissues but are potentially effective chemotherapeutic agents for colon cancer

Wheat Variety Test Results for South Central Kansas - 2022

South central Kansas is the highest producing wheat region in Kansas. This report summarizes the results of winter wheat variety tests for 2021-2022 in six locations

Guidance of adjuvant instillation in intermediate-risk non-muscle invasive bladder cancer by drug screens in patient derived organoids: a single center, open-label, phase II trial.

BACKGROUND In intermediate-risk non-muscle invasive bladder cancer (NMIBC) clinical guidelines suggest an adjuvant instillation with a chemotherapeutic agent. However, the agent and regimen are not clearly defined. Worldwide, less than 15% of patients receive this adjuvant chemotherapeutic instillation. We recently developed a pipeline for the generation of patient derived organoids (PDO) in NMIBC. In this phase II trial, we aim to use our in vitro pipeline to select the most effective drug for chemotherapeutic instillation in NMIBC patients. METHODS Patients with first diagnosis of intermediate-risk NMIBC that are directed to transurethral resection of bladder tumor (TURBT) are enrolled. During TURBT, tumor is sampled, and specimens are directed to generate PDO. Once the PDO are formed, drug screens on them for Epirubicin, Mitomycin C, Gemcitabine and Docetaxel are performed. The drug with the highest antitumor activity in vitro will then be selected for 6 adjuvant intravesical instillations once weekly. Thereafter, patients are followed according to clinical guidelines by cystoscopy. DISCUSSION The aim of this trial is to use drug screens in PDO to precise treatment selection for adjuvant instillation therapies in patients with intermediate-risk NMIBC. The ultimate goal of this trial is to reduce the risk of cancer recurrence. In the future, we aim to conduct clinical multicenter trials with an increased sample size, a broader panel of compounds and a focus on the reduction of cancer recurrence by precision delivery of care. Trial registration NCT05024734

Constraint-preserving boundary treatment for a harmonic formulation of the Einstein equations

We present a set of well-posed constraint-preserving boundary conditions for a first-order in time, second-order in space, harmonic formulation of the Einstein equations. The boundary conditions are tested using robust stability, linear and nonlinear waves, and are found to be both less reflective and constraint preserving than standard Sommerfeld-type boundary conditions.Comment: 18 pages, 7 figures, accepted in CQ

Comparison between Anterior Corneal Aberration and Ocular Aberration in Laser Refractive Surgery

Purpose: To compare changes of anterior corneal aberration (Pentacam®) and ocular aberration (aberrometer, LADARWave®) after laser refractive surgery. Methods: Sixty-six eyes underwent laser refractive surgery and were retrospectively reviewed. Anterior corneal aberration and ocular aberration were measured by Pentacam ® and an aberrometer (LADARWave®) respectively. Changes of root mean square (RMS) values of coma, spherical aberration, and total high order aberration (HOA) were evaluated before, 1 month, and 3 months after surgery Results: Ocular aberrations displayed low preoperative values, but after laser refractive surgery, anterior corneal aberration and ocular aberration increased equally. There were no statistically significant differences of internal optics aberration values (ocular aberration minus anterior corneal aberration) in coma, spherical aberration, and total HOA. Anterior corneal aberration and ocular aberration showed statistically significant correlations at 1 and 3 months after surgery. Conclusions: Internal optics aberration compensated the anterior corneal aberration effectively before surgery, but the increase of anterior corneal aberration after laser refractive surgery exceeded the compensation of internal optics. As a result, anterior corneal aberration and ocular aberration increased equally. The correlation between anterior corneal aberration and ocular aberration after surgery was statistically significant due to the increased proportion of anterior corneal aberration in ocular aberration. Korean J Ophthalmol 2008;22:164-168 ⓒ 2008 by the Korean Ophthalmological Society

Rapid evolution of A(H5N1) influenza viruses after intercontinental spread to North America

Highly pathogenic avian influenza A(H5N1) viruses of clade 2.3.4.4b underwent an explosive geographic expansion in 2021 among wild birds and domestic poultry across Asia, Europe, and Africa. By the end of 2021, 2.3.4.4b viruses were detected in North America, signifying further intercontinental spread. Here we show that the western movement of clade 2.3.4.4b was quickly followed by reassortment with viruses circulating in wild birds in North America, resulting in the acquisition of different combinations of ribonucleoprotein genes. These reassortant A(H5N1) viruses are genotypically and phenotypically diverse, with many causing severe disease with dramatic neurologic involvement in mammals. The proclivity of the current A(H5N1) 2.3.4.4b virus lineage to reassort and target the central nervous system warrants concerted planning to combat the spread and evolution of the virus within the continent and to mitigate the impact of a potential influenza pandemic that could originate from similar A(H5N1) reassortants

Screensaver: an open source lab information management system (LIMS) for high throughput screening facilities

<p>Abstract</p> <p>Background</p> <p>Shared-usage high throughput screening (HTS) facilities are becoming more common in academe as large-scale small molecule and genome-scale RNAi screening strategies are adopted for basic research purposes. These shared facilities require a unique informatics infrastructure that must not only provide access to and analysis of screening data, but must also manage the administrative and technical challenges associated with conducting numerous, interleaved screening efforts run by multiple independent research groups.</p> <p>Results</p> <p>We have developed Screensaver, a free, open source, web-based lab information management system (LIMS), to address the informatics needs of our small molecule and RNAi screening facility. Screensaver supports the storage and comparison of screening data sets, as well as the management of information about screens, screeners, libraries, and laboratory work requests. To our knowledge, Screensaver is one of the first applications to support the storage and analysis of data from both genome-scale RNAi screening projects and small molecule screening projects.</p> <p>Conclusions</p> <p>The informatics and administrative needs of an HTS facility may be best managed by a single, integrated, web-accessible application such as Screensaver. Screensaver has proven useful in meeting the requirements of the ICCB-Longwood/NSRB Screening Facility at Harvard Medical School, and has provided similar benefits to other HTS facilities.</p